Leptin therapy in lipodystrophy
نویسندگان
چکیده
منابع مشابه
Leptin: a novel therapeutic role in lipodystrophy.
Lipodystrophic syndromes encompass a heterogeneous group of rare disorders characterized by partial or generalized loss of adipose tissue depots (1). They are commonly associated with dyslipidemia, hepatic steatosis, and severe insulin resistance (2). The fact that insulin resistance and the consequent progression to diabetes can result from either obesity or lipodystrophy reflects the crucial ...
متن کاملEffects of Leptin Replacement Therapy on Pancreatic b-Cell Function in Patients With Lipodystrophy
In a prospective, open-label, currently ongoing study we studied the effects of leptin replacement on b-cell function in 13 patients with congenital or acquired lipodystrophy. Insulin secretory rate (ISR) was calculated by C-peptide deconvolution from plasma glucose and C-peptide levels measured during oral glucose tolerance tests (OGTTs) performed at baseline and after 16–20 weeks of leptin re...
متن کاملEffects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy
OBJECTIVE Leptin administration is known to directly modulate pancreatic β-cell function in leptin-deficient rodent models. However, human studies examining the effects of leptin administration on β-cell function are lacking. In this study, we examined the effects (16-20 weeks) of leptin replacement on β-cell function in patients with lipodystrophy. RESEARCH DESIGN AND METHODS In a prospective,...
متن کاملResistance to leptin-replacement therapy in Berardinelli-Seip congenital lipodystrophy: an immunological origin.
CONTEXT Recently, in a 4-month proof-of-concept trial, beneficial metabolic effects were reported in non-diabetic children with Berardinelli-Seip congenital lipodystrophy (BSCL); this information prompted us to hypothesize that long-term leptin-replacement therapy might improve or reverse the early complications of the disease in these patients. PATIENTS AND METHODS A 28-month trial was imple...
متن کاملTranslational Research of Leptin in Lipodystrophy and Its Related Diseases
Leptin, an adipocyte-derived hormone, plays crucial roles in the regulation of energy expenditure and food intake. Through analyses of leptin transgenic mice, we have demonstrated that leptin has pleiotropic effects such as regulation of insulin sensitivity and lipid metabolism. Lipodystrophy is a disease characterized by a lack of adipose tissue, which leads to metabolic disorders including in...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2009
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-009-1545-y